In diabetes mellitus there is an increase in oxygen radical formation due to glucose auto oxidation, the formation of advanced glycosylation end products, and metabolic stress. Epidemiologic studies suggest that vitaminE supplementation might decrease the risk of developing cardiovascular disease, others showed increased risk of cardiac death with the vitamin E treatment.
To the contradictory results in the literature regarding the beneficial role of vitamin E in protecting against cardiovascular complications, high dose vitamin E supplementation has not been recommended by the medical community. In fact, a meta-analysis of over 135000 individuals treated with vitamin E concluded that high dose vitamin E slightly increases the risk of mortality.
However, recent investigations into the polymorphic serum protein haptoglobin (Hp) indicate that vitamin E may be beneficial in a genetically defined subgroup of patients, namely, diabetic patients of the Hp 2-2 genotype.
The role of Hp as an antioxidant, its importance in diabetes, and the therapeutic role of vitaminE will be showcased during Targeting Targeting Liver Diseases 2014 by Dr Farid Nakhoul.
For more information: www.targeting-liver.com
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